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The opioid overdose and death epidemic continues to worsen across the United States, but medications such as methadone, buprenorphine, and extended-release naltrexone are proven to reduce opioid overdoses by more than 50 percent. New findings led by researchers at NYU Grossman School of Medicine indicate the vast majority, or 86.6 percent, of people living with opioid use disorder (OUD) are not receiving these evidence-based, lifesaving medications.

Published online August 4 in the International Journal of Drug Policy, the study examined the gap between new estimates of OUD prevalence and the use of medications for OUD (MOUD) at the national and state levels from 2010 through 2019. Although the use of MOUD has grown by more than 100 percent over the last decade, this rise in treatment has failed to keep pace with OUD and skyrocketing overdose mortality rates—largely driven by fentanyl, a potent synthetic opioid up to 50 times stronger than heroin.

A recent report from the Centers for Disease Control and Prevention revealed opioid overdose deaths climbed 30 percent during the first year of the COVID-19 pandemic nationally, with Black, American Indian, and Alaska Native populations bearing disproportionate shares of the increase.

“Our findings highlight the urgency of removing barriers to accessing medications to treat opioid use disorder, while expanding the availability of these medications,” says Noa Krawczyk, PhD, an assistant professor in the Department of Population Health, a member of the Center for Opioid Epidemiology and Policy at NYU Langone, and lead author of the study. “But what we have is way beyond a simple treatment capacity problem. We need to rethink how treatment for opioid use disorder is delivered, eliminate stigma, make it easier for people to enter and remain in treatment, as well as ensure that all treatment programs provide and encourage use of evidence-based medications that we know save lives.”

According to Dr. Krawczyk, more than 70 percent of residential treatment programs across the country do not offer MOUD. Other ways to expand access to MOUD could include removing special waiver requirements so that more physicians can prescribe buprenorphine, as well as expanding the deployment of MOUD by mobile health clinics and community-based organizations, and within the criminal justice system. Making methadone less controlled and more accessible through avenues other than highly regulated opioid treatment programs is also long overdue, says Dr. Krawczyk.

To determine the gap between people with OUD and the number of people receiving MOUD, the investigators analyzed two different sources: a publicly available database that tracks the dispensing of MOUD by licensed methadone clinics and a private database of outpatient pharmacy claims that tracks prescriptions filled for buprenorphine and extended-release naltrexone (MOUD that can be prescribed from a doctor’s office). The researchers then calculated the percent change in national and state-specific rates of persons receiving MOUD over the past year (2018 to 2019) and past decade (2010 to 2019), using rates per 100,000 people. Their analysis revealed the following findings:

“Even in states with the smallest treatment gaps, at least 50 percent of people who could benefit from medications for opioid use disorder are still not receiving them,” says Magdalena Cerdá, DrPH, a professor in the Department of Population Health, director of the Center for Opioid Epidemiology and Policy, and the study’s senior author. “We have a long way to go in reducing stigma surrounding treatment and in devising the types of policies and programs we need to ensure these medications reach the people who need them the most,” says Dr. Cerdá.

In addition to Dr. Krawczyk and Dr. Cerdá, study co-authors from NYU Grossman School of Medicine are Bianca D. Rivera, MPH, CPH, and Victoria Jent, MPH. Additional co-authors are Katherine M. Keyes, PhD, MPH, from the Mailman School of Public Health, Columbia University; and Christopher M. Jones, PharmD, DrPH, MPH, from the National Center for Injury Prevention and Control, Centers for Disease Control and Prevention.

The study was supported by NYU Langone’s Center for Opioid Epidemiology and Policy.

Sasha Walek Phone: 646-501-3873 sasha.walek@nyulangone.org

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